Give up, quit, leave or abandon—such as jumping out of a bus with other people aboard.
Jumping off to avoid a dangerous situation can represent escaping an unwanted situation in real life.
Jumping to your death, such as off of a tall building, can represent feelings of frustration or wanting to escape from something in real life.
Jumping off for fun or thrills, such as bungee jumping or skydiving can represent a desire for excitement or freedom.